Curr Biol：分散注意力可有效性缓解疼痛感

亦同，刊登在国际著名杂志Cell的子刊Current Biology上的一篇熟悉研究报告引述，利用本质干扰（分心）的方法可以使得眼部消除，然而这种眼部缓解消除的效应并不表现在颈部。这项熟悉研究发现是基于采用高分辨率的骨髓机能性磁共振激光系统设计（fMRI系统设计），对人们由于冷却引起的眼部素质进行熟悉研究，熟悉研究阐释，本质干扰确实可以在中枢眼部处理早期抑制眼部接收机的传布。来自科隆-埃甘多夫大学学院的熟悉历史学者Christian Sprenger表示，这种物理现象并不仅仅是一种本质物理现象，而是一种热衷于的神经元必要，可以降低从脊髓上升至大脑高级地带的眼部接收机。

这种效应涉及到了内源性的类微粒，这种微粒产生自大脑，在消除眼部的流程中扮演重要片中。熟悉研究人员让参加者分别完成一个简单或者一个较易的记忆性任务，需要他们记住信件的象形文字内容，同时给参加者肩膀上伤及冷却。进行较易任务的参加者变得心烦意乱时，他们时会令人极小的眼部，通过fMRI系统设计反映出这些参加者的脊髓地带活性变得比较低，fMRI通常是用来测定大脑活性的改变。

Sprenger和他的同事然后重复了实验室，这次他们给予参加者一种药物-钠洛酮（抗休克的很好药物，可以阻挡阿司匹林的效应）或者一般而言的安平注入，结果显示，相比只注入一般而言安平的参加者，采用阿司匹林拮抗剂的参加者由于注意力分散，引起的眼部缓解降低了40%，因此得出结论内源性的扮演重要作用。

熟悉历史学者的发现阐释了本质流程可以熟悉地改变人们的眼部经历，并且对于临床也有更为重要的意义。熟悉历史学者表示，我们的熟悉研究发现给眼部疾病治疗给予了本质犯罪行为治疗的方法。（生物谷：T.Shen编译）

doi:10.1016/j.cub.2012.04.006PMC:PMID:

Attention Modulates Spinal Cord Responses to Pain

Christian Sprenger1, , , Falk Eippert1, Jürgen Finsterbusch1, Ulrike Bingel1, 2, Michael Rose1, Christian Büchel1

Reduced pain perception while being distracted from pain is an everyday example of how cognitive processes can interfere with pain perception [ [1], [2], [3], [4] and [5]]. Previous neuroimaging studies showed distraction-related modulations of pain-driven activations in various cortical and subcortical brain regions [ [6], [7], [8], [9], [10] and [11]], but the precise neuronal mechanism underlying this phenomenon is unclear. Using high-resolution functional magnetic resonance imaging of the human cervical spinal cord in combination with thermal pain stimulation and a well-established working memory task [12], we demonstrate that this phenomenon relies on an inhibition of incoming pain signals in the spinal cord. Neuronal responses to painful stimulation in the dorsal horn of the corresponding spinal segment were significantly reduced under high working memory load compared to low working memory load. At the individual level, reductions of neuronal responses in the spinal cord predicted behioral pain reductions. In a subsequent behioral experiment, using the opioid antagonist naloxone in a double-blind crossover design with the same paradigm, we demonstrate a substantial contribution of endogenous opioids to this mechanism. Taken together, our results show that the reduced pain experience during mental distraction is related to a spinal process and involves opioid neurotransmission.